iPS细胞可在胚胎中正常发育吗?
来源:学生作业帮 编辑:作业帮 分类:英语作业 时间:2024/07/06 01:39:47
iPS细胞可在胚胎中正常发育吗?
iPS细胞可在胚胎中正常发育
To our knowledge,for the first time,we demonstrate that induced pluripotent stem cells (iPSCs) can autonomously generate full-term mice via tetraploid blastocysts complementation.Differentiated somatic cells can be reprogrammed into iPSCs by forced expression of four transcription factorsOct4,Sox2,Klf4,and c-Myc.However,it has been unclear whether reprogrammed iPSCs are fully pluripotent,resembling normal embryonic stem cells (ESCs),as no iPSC lines have shown the ability to autonomously generate full-term mice after injection into tetraploid blastocysts.Here we provide evidence demonstrating that an iPSC line induced by the four transcription factors can be used to generate full-term mice from complemented tetraploid blastocysts and thus appears to be fully pluripotent.This work serves asa proof of principle that iPSCs can in fact generate full-term embryos by tetraploid complementation.
To our knowledge,for the first time,we demonstrate that induced pluripotent stem cells (iPSCs) can autonomously generate full-term mice via tetraploid blastocysts complementation.Differentiated somatic cells can be reprogrammed into iPSCs by forced expression of four transcription factorsOct4,Sox2,Klf4,and c-Myc.However,it has been unclear whether reprogrammed iPSCs are fully pluripotent,resembling normal embryonic stem cells (ESCs),as no iPSC lines have shown the ability to autonomously generate full-term mice after injection into tetraploid blastocysts.Here we provide evidence demonstrating that an iPSC line induced by the four transcription factors can be used to generate full-term mice from complemented tetraploid blastocysts and thus appears to be fully pluripotent.This work serves asa proof of principle that iPSCs can in fact generate full-term embryos by tetraploid complementation.
在胚胎发育过程中,基因选择性表达,细胞会产生新的蛋白质吗
胚胎发育与细胞()、()有关
胚胎发育中的细胞分化不会终止吗
在胚胎发育中发生的基因突变是遗传病吗
胚胎发育(受精卵细胞开始分裂)的起点是在母体的哪个部位?
鸡的胚胎发育和人的胚胎发育都经历了细胞的什么过程?
胚胎发育
在胚胎发育过程中,基因选择性表达,细胞会产生新的蛋白质吗,这些新蛋白质是怎么个新法,是相对于什么而言
科学家将人体皮肤细胞成功改造成“iPS”细胞,此细胞可以和人胚胎干细胞相媲美.“iPS”细胞最终能被培育成人体的多种组织
从细胞水平看来,鸡的胚胎发育与人的胚胎发育类似,胚胎发育过程中都发生了细胞的什么变化(看问题补充)
胚胎发育从细胞开始变一直变到什么?
鸟类的胚胎在发育鸟类的胚胎在____(体内或体外)发育