作业帮英语翻译The role of the intracellular signaling pathways activat
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英语翻译
The role of the intracellular signaling pathways activated by PTH and PTHrP,which regulate the cell cycle in osteoblasts,are yet to be defined.PTH has been shown to inhibit osteoblast proliferation by increasing p27 levels and inhibiting CDK2 activity [223].Gene array analysis showed differential expressions of cyclins,Bcl-2 family members,as well as p53 during differentiation of a mouse calvarial-derived cell line to acquire an osteoblast like phenotype [224].PTHrP,on the other hand,has been shown to target cyclin D1,CDK1 p21,p27 and p16 protein in differentiated osteoblasts and induced G1 phase growth arrest [61].In differentiated osteoblasts,PTHrP reduces CDK1 activity and down-regulates cyclin D1 level possibly via decreased phosphorylation and stabilization of JunB,a member of AP-1 transcription factor [61].
The role of the intracellular signaling pathways activated by PTH and PTHrP,which regulate the cell cycle in osteoblasts,are yet to be defined.PTH has been shown to inhibit osteoblast proliferation by increasing p27 levels and inhibiting CDK2 activity [223].Gene array analysis showed differential expressions of cyclins,Bcl-2 family members,as well as p53 during differentiation of a mouse calvarial-derived cell line to acquire an osteoblast like phenotype [224].PTHrP,on the other hand,has been shown to target cyclin D1,CDK1 p21,p27 and p16 protein in differentiated osteoblasts and induced G1 phase growth arrest [61].In differentiated osteoblasts,PTHrP reduces CDK1 activity and down-regulates cyclin D1 level possibly via decreased phosphorylation and stabilization of JunB,a member of AP-1 transcription factor [61].
现在没时间了,我下班以后到家再试试看,回家修改答案,你这个太专业了,我只能翻译大体意思,具体的还是需要你的专业知识.
全文翻译的太难了,你最好找一个生物学的博士.
我勉强帮你翻译这段.
细胞内的信号路径通过PTH和PTHrP激活,从而调节细胞周期中的成骨细胞的作用,还有待确定.PHT已被证明能够通过抑制p27蛋白水平增加来抑制成骨细胞的增值,同时抑制CDK2的活性.基因阵列分析表明,细胞周期蛋白表达差异,Bcl - 2的家族成员,以及p53在从源于老鼠颅骨细胞株变异期间表型成骨细胞.从另一方面讲,PTHrP已被证明以细胞周期蛋白D1,CDK1,p21,p27和p16蛋白质为目标分化为成骨蛋白和诱导G1期生长停滞.在已分化的成骨细胞中,PTHrP可能通过减少AP-1转录因子成员之一的JunB稳定性和磷酸化作用降低CDK1的活性和抑制细胞周期蛋白D1的水平.
太TMD的难了.
全文翻译的太难了,你最好找一个生物学的博士.
我勉强帮你翻译这段.
细胞内的信号路径通过PTH和PTHrP激活,从而调节细胞周期中的成骨细胞的作用,还有待确定.PHT已被证明能够通过抑制p27蛋白水平增加来抑制成骨细胞的增值,同时抑制CDK2的活性.基因阵列分析表明,细胞周期蛋白表达差异,Bcl - 2的家族成员,以及p53在从源于老鼠颅骨细胞株变异期间表型成骨细胞.从另一方面讲,PTHrP已被证明以细胞周期蛋白D1,CDK1,p21,p27和p16蛋白质为目标分化为成骨蛋白和诱导G1期生长停滞.在已分化的成骨细胞中,PTHrP可能通过减少AP-1转录因子成员之一的JunB稳定性和磷酸化作用降低CDK1的活性和抑制细胞周期蛋白D1的水平.
太TMD的难了.
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