英语翻译在过去的十几年里,随着人们对肿瘤发病机理的深入了解,一些在肿瘤发生过程中起重要作用的信号分子随之被发现,并且已经

英语翻译
在过去的十几年里,随着人们对肿瘤发病机理的深入了解,一些在肿瘤发生过程中起重要作用的信号分子随之被发现,并且已经成为药物作用的新靶点.在这些靶点当中,酪氨酸激酶成为研究的热点.目前大多数的EGFR抑制剂属于ATP竞争性抑制剂,其部分结构片断具有与ATP中腺嘌呤相似的结构特点.基于此特点并结合文献报道的EGFR抑制剂的结构特征,本论文以嘌呤类似物喹唑啉为母核,分别在其4位和7位引入结构多样的取代苯氨基和柔性侧链,设计了一系列4-取代苯胺-6-(2-羟基取代丙氧基)-喹唑啉类化合物.以香草酸为起始原料,经过酯化、硝化、还原、环合、氯代、取代、醚化等反应,合成了两个未见文献报道的目标化合物.化合物的结构经1H NMR和MS确证.

In the past decade,the deepened comprehension of the tumor pathogenesis has lead to the discovery of the “signaling molecules” which play important roles in the tumor occurrence.These “signaling molecules” have become new pharmaceutical targets among which the tyrosine kinase attracts significant research interest.Currently,many of the EGFR inhibitors,which comprise structural fragments similar to the adenine group of ATP,are in the category of ATP competitive inhibitors.Based on the abovementioned structural characteristic and with a reference to the molecule structures of many EGFR inhibitors previous reported,this article describes the design of a series of 4-substituted anilino -6-(2-hydroxypropyloxy)-quinazoline derivatives,which consist of a quinazoline (the purine analog) nucleus with various substituted anilino groups and flexible side-chains on its 4- and 7- position.In this article,two previously unreported compounds were synthesized from vanillic acid through the esterization,nitration,reduction,cyclization,chloro-substitution,substitution and etherization reactions.The structure of the compounds were characterized by 1H NMR and MS.
楼主,关键词很多,要仔细核对参考文献啊.