英语翻译The transport of hydrophilic macromolecules via the para
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英语翻译
The transport of hydrophilic macromolecules via the paracellular pathway is,however,
severely restricted by the presence of tight junctions which are located at the luminal aspect of adjacent epithelial cells.[ 5 ]Tight junctions consist of a complex of trans-membrane (e.g.,occuludin,claudin,JAM) and cytoplasmic (e.g.,ZO-1,ZO-2,ZO-3,cingulin) proteins and are dynamically regulated by complex physiological mechanisms.[ 6 ] ZO-1 proteins are thought to be a linkage molecule between occludin and actin cytoskeleton and play important roles in the rearrangement of cell–cell contacts.
The transport of hydrophilic macromolecules via the paracellular pathway is,however,
severely restricted by the presence of tight junctions which are located at the luminal aspect of adjacent epithelial cells.[ 5 ]Tight junctions consist of a complex of trans-membrane (e.g.,occuludin,claudin,JAM) and cytoplasmic (e.g.,ZO-1,ZO-2,ZO-3,cingulin) proteins and are dynamically regulated by complex physiological mechanisms.[ 6 ] ZO-1 proteins are thought to be a linkage molecule between occludin and actin cytoskeleton and play important roles in the rearrangement of cell–cell contacts.
然而,通过旁细胞途径的亲水性大分子的输送,被位于相邻的上皮细胞的细胞腔的紧密联结所严格限制.[5] 紧密联结由一个复杂的贯穿膜(例如,连接蛋白,封闭蛋白,联结黏附分子)和细胞质蛋白质组成(例如,ZO- 1,ZO- 2,ZO- 3,扣带蛋白)同时被一种复杂的生理机制动态地控制着.[6] ZO -1蛋白被认为是一个闭锁蛋白和肌动蛋白细胞骨架之间的联结分子,并在细胞与细胞联系的重新排列中发挥重要作用.
JAM:Junction Adhesion Molecule 联结黏附分子
cingulin 扣带蛋白
occludin 闭锁蛋白
JAM:Junction Adhesion Molecule 联结黏附分子
cingulin 扣带蛋白
occludin 闭锁蛋白
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